Plasmodium falciparum isolates from infected pregnant women and children are associated with distinct adhesive and antigenic properties
- Author(s)
- Beeson, JG; Brown, GV; Molyneux, ME; Mhango, C; Dzinjalamala, F; Rogerson, SJ;
- Details
- Publication Year 1999-08,Volume 180,Issue #2,Page 464-472
- Journal Title
- JOURNAL OF INFECTIOUS DISEASES
- Publication Type
- Journal Article
- Abstract
- Plasmodium falciparum malaria during pregnancy is an important cause of maternal and infant morbidity and mortality. Accumulation of large numbers of P. falciparum-infected erythrocytes in the maternal blood spaces of the placenta may be mediated by adhesion of infected erythrocytes to molecules presented on the syncytiotrophoblast surface, In this study, isolates from placentas and peripheral blood of infected pregnant women and from children were tested for binding to purified receptors and for agglutination with adult sera. Results suggest that adhesion to chondroitin sulfate A may be involved in placental parasite sequestration in most cases, but other factors are also likely to be important, Agglutination assay results suggest that parasites infecting pregnant women are antigenically distinct from those common in childhood disease. The prevalence of agglutinating antibodies to pregnancy isolates was generally low, but it was highest in multigravidae who are likely to have had the greatest exposure.
- Publisher
- UNIV CHICAGO PRESS
- Keywords
- CHONDROITIN SULFATE-A; CEREBRAL MALARIA; MEMBRANE GLYCOPROTEIN; ADHERENCE RECEPTOR; HUMAN-ERYTHROCYTES; HUMAN PLACENTA; SURFACE; CYTOADHERENCE; SEQUESTRATION; MOLECULE-1
- Publisher's Version
- https://doi.org/10.1086/314899
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-08-01 12:00:00