p75 neurotrophin receptor-mediated neuronal death is promoted by Bcl-2 and prevented by Bcl-x(L)
- Author(s)
- Coulson, EJ; Reid, K; Barrett, GL; Bartlett, PF;
- Details
- Publication Year 1999-06-04,Volume 274,Issue #23,Page 16387-16391
- Journal Title
- JOURNAL OF BIOLOGICAL CHEMISTRY
- Publication Type
- Journal Article
- Abstract
- The p75 neurotrophin receptor (p75NTR) has been shown to mediate neuronal death through an unknown pathway. We microinjected p75NTR expression plasmids into sensory neurons in the presence of growth factors and assessed the effect of the expressed proteins on cell survival. We show that, unlike other members of the TNFR family, p75NTR signals death through a unique caspase-dependent death pathway that does not involve the "death domain" and is differentially regulated by Bcl-2 family members: the anti-apoptotic molecule Bcl-2 both promoted, and was required for, p75NTR killing, whereas killing was inhibited by its homologue BcI-x(L). These results demonstrate that Bcl-2, through distinct molecular mechanisms, either promotes or inhibits neuronal death depending on the nature of the death stimulus.
- Publisher
- AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
- Keywords
- NERVE GROWTH-FACTOR; LEUKEMIA INHIBITORY FACTOR; CELL-DEATH; NMR STRUCTURE; PC12 CELLS; APOPTOSIS; DOMAIN; BAX; EXPRESSION; SURVIVAL
- Publisher's Version
- https://doi.org/10.1074/jbc.274.23.16387
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-06-04 12:00:00