Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector
- Author(s)
- Adams, JM; Harris, AW; Strasser, A; Ogilvy, S; Cory, S;
- Details
- Publication Year 1999-09-20,Volume 18,Issue #38,Page 5268-5277
- Journal Title
- ONCOGENE
- Publication Type
- Journal Article
- Abstract
- The pathways to lymphoid neoplasia have been explored in a number of transgenic models. Because B lymphoid malignancies often involve translocation of an oncogene (e.g, myc, bcl-2, cyclin D1) to an immunoglobulin locus, resulting in its deregulated expression, the consequences of oncogene overexpression in lymphocytes can be evaluated with transgenes driven by an immunoglobulin regulatory element, such as an enhancer from the IgH locus. Mice bearing such transgenes have provided insight into the preneoplastic state, including alterations in the control of cellular proliferation, differentiation or apoptosis. They have also allowed studies on oncogene cooperation in,tiro and the modulating effect of genetic background. Briefly reviewed here are the models studied in the authors' Laboratories. Mice bearing myc and bcl-2 transgenes have received most attention but others studied include abl, ras, cyclin D1 and bmi-1 oncogenes. Also discussed is a new transgenic vector that should facilitate transgenic approaches to non-lymphoid leukemias, The vector bears elements from the promoter region of the vav gene, which is expressed almost exclusively in hematopoietic cells. It has proven capable of driving transgene expression throughout the hematopoietic compartment, including progenitor cells and their precursors. This novel vector should aid studies on many aspects of hematopoiesis, including the modeling of leukemogenesis.
- Publisher
- STOCKTON PRESS
- Keywords
- E-MU-MYC; CHRONIC MYELOGENOUS LEUKEMIA; POSITION-EFFECT VARIEGATION; PROGRAMMED CELL-DEATH; PRE-B-CELLS; C-MYC; T-CELL; V-ABL; N-MYC; VAV PROTOONCOGENE
- Publisher's Version
- https://doi.org/10.1038/sj.onc.1202997
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-09-20 12:00:00