Proapoptotic Bcl-2 relative bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
- Author(s)
- Bouillet, P; Metcalf, D; Huang, DCS; Tarlinton, DM; Kay, TWH; Kontgen, F; Adams, JM; Strasser, A;
- Details
- Publication Year 1999-11-26,Volume 286,Issue #5445,Page 1735-1738
- Journal Title
- SCIENCE
- Publication Type
- Journal Article
- Abstract
- Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim, that share only the BH3 domain with this family. Gene targeting in mice revealed important physiological lores for sim. Lymphoid and myeloid cells accumulated, T cell development was perturbed, and most older mice accumulated plasma cells and succumbed to autoimmune kidney disease. Lymphocytes were refractory to apoptotic stimuli such as cytokine deprivation, calcium ion flux, and microtubule perturbation but not to others. Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins.
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Keywords
- CELL-DEATH; PROTEIN; FAMILY; MICE; ACTIVATION; THYMOCYTES; CASPASE-9; SURVIVAL; PATHWAYS; DELETION
- Publisher's Version
- https://doi.org/10.1126/science.286.5445.1735
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-11-26 12:00:00