New insights into the roles of ReL/NF-kappa B transcription factors in immune function, hemopoiesis and human disease
- Author(s)
- Grossmann, M; Nakamura, Y; Grumont, R; Gerondakis, S;
- Details
- Publication Year 1999-10,Volume 31,Issue #10,Page 1209-1219
- Journal Title
- INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- In mammals, Rel/NF-kappa B proteins are a small family of transcription factors which serve as pivotal regulators of immune, inflammatory and acute phase responses. Pathways leading to the activation of Rel/NF-kappa B have recently been dissected in some detail and shown to converge on a unique high molecular weight cytoplasmic complex that includes several kinases and regulatory molecules. Moreover, gene targeting experiments have identified novel roles for Rel/NF-kappa B proteins in the development and maturation of hemopoietic precursors as well as in the function of mature cells in the immune system. These include regulating the cell cycle, controlling cell survival and providing a link between the innate and adaptive immune systems. Since the dysregulation of Rel/NF-kappa B function is associated with various pathologies including inflammatory and neoplastic disease, new insights into the role of Rel/NF-kappa B in human disease may provide a basis for therapeutic strategies in the treatment of chronic inflammatory diseases and certain malignancies. (C) 1999 Elsevier Science Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- KINASE COMPLEX; INDUCED APOPTOSIS; MICE LACKING; CELL-DEATH; IKK-ALPHA; ACTIVATION; PROTEIN; PHOSPHORYLATION; REQUIREMENT; EXPRESSION
- Publisher's Version
- https://doi.org/10.1016/S1357-2725(99)00068-0
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-10-01 12:00:00