The beta common chain (beta c) of the granulocyte macrophage-colony stimulating factor, interleukin-3 and iaterleukin-5 receptors
- Author(s)
- Scott, CL; Begley, CG;
- Details
- Publication Year 1999-10,Volume 31,Issue #10,Page 1011-1015
- Journal Title
- INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- The hematopoietic cytokines granulocyte-macrophage colony-stimulating factor (GM-CSF), Interleukin (IL)-5 and IL-3 utilise a common receptor signalling molecule, the beta common chain (beta c). This shared receptor component explains, in part the overlapping actions of these cytokines. Mice lacking beta c have a low circulating eosinophil level, have impaired eosinophilic responses to parasitic infection and develop lung disease analagous to human pulmonary alveolar proteinosis (PAP). Surprisingly however, mature hematopoietic cell function is relatively intact, although all GM-CSF-mediated mature cell responses, including glucose transport are absent. Intriguing observations suggesting altered susceptibility to some infectious agents and amelioration of responses to inflammatory stimuli, require further clarification. (C) 1999 Elsevier Science Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- FACTOR-DEFICIENT MICE; FACTOR GM-CSF; HEMATOPOIETIC RESPONSE; ALVEOLAR PROTEINOSIS; SUBUNIT; CELLS; PATHOLOGY; LACKING; IL-3
- Publisher's Version
- https://doi.org/10.1016/S1357-2725(99)00077-1
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-10-01 12:00:00