Dendritic cell origins: Puzzles and paradoxes
- Author(s)
- Vandenabeele, S; Wu, L;
- Details
- Publication Year 1999-10,Volume 77,Issue #5,Page 411-419
- Journal Title
- IMMUNOLOGY AND CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- In the present review, a series of studies on the origins of dendritic cells of mice and humans are summarized. Several subsets of mature dendritic cells found in vivo are described and these may correspond to distinct lineages. There is evidence that some dendritic cells are myeloid-derived and that others are lymphoid-derived. The different ways of generating dendritic cells are examined and an attempt to reconcile the differences seen using mouse and human culture models is made. The particular case of Langerhans cells is discussed and an historical overview of the biology of the plasmacytoid T cells, which may represent a distinct 'lymphoid-related' dendritic cell lineage, is given. It is concluded that three or four different pathways lead to the development of different subtypes of dendritic cells.
- Publisher
- BLACKWELL SCIENCE ASIA
- Keywords
- PLASMACYTOID T-CELLS; COLONY-STIMULATING FACTOR; EPIDERMAL LANGERHANS CELLS; HUMAN PERIPHERAL-BLOOD; TUMOR-NECROSIS-FACTOR; CD34(+) HEMATOPOIETIC PROGENITORS; HUMAN BONE-MARROW; NATURAL-KILLER; STEM-CELLS; IN-VITRO
- Publisher's Version
- https://doi.org/10.1046/j.1440-1711.1999.00857.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-10-01 12:00:00