Effect of adrenocorticotrophic hormone on sodium appetite in mice
- Author(s)
- Denton, DA; Blair-West, JR; McBurnie, MI; Miller, JAP; Weisinger, RS; Williams, RM;
- Details
- Publication Year 1999-10,Volume 277,Issue #4,Page R1033-R1040
- Journal Title
- AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Publication Type
- Journal Article
- Abstract
- A main vector of the effects of stress is secretion of corticotrophin releasing factor (CRF), adrenocorticotrophin (ACTH), and adrenal steroids. Systemic administration of ACTH (2.8 mu g/day sc) for 7 days in BALB/c mice caused a very large increase of voluntary intake of 0.3 M NaC1 equivalent to turnover of total body sodium content each day. Intracerebroventricular infusion of ACTH (20 ng/ day) had no effect. Intracerebroventricular infusion of ovine CRF (10 ng/h for 7 days) caused an increase of sodium intake. The large sodium appetite-stimulating effect of systemic ACTH was not influenced by concurrent systemic infusion of captopril (2 mg/day). Induction of stress by immobilization of mice on a running wheel caused an increase in Na appetite associated with a 50% decrease of thymus weight, indicative of corticosteroid effects. The present data suggest that stress and the hormone cascade initiated by stress evoke a large sodium appetite in mice, which may be an important survival mechanism in environmental conditions causing stress.
- Publisher
- AMER PHYSIOLOGICAL SOC
- Keywords
- ANGIOTENSIN-II; SALT APPETITE; BALB/C MICE; BLOOD-PRESSURE; WATER-INTAKE; NA APPETITE; FOOD-INTAKE; STRESS; RABBITS; SHEEP
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-10-01 12:00:00