LIM-kinase 1
- Author(s)
- Stanyon, CA; Bernard, O;
- Details
- Publication Year 1999-03,Volume 31,Issue #3-4,Page 389-394
- Journal Title
- INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- LIM-kinasel (LIMK1) is a serine-only protein kinase that contains LIM and PDZ protein-protein interaction domains which is highly expressed in neurons. Overexpression of LIMK1 in cultured cells results in accumulation of filamentous (F-) actin. LIMK1 phosphorylates cofilin, an actin depolymerisation factor, which is then unable to bind and depolymerise F-actin. Rac-GTP enhances phosphorylation of LIMK1 and cofilin, which leads to accumulation of F-actin, while Rac-GDP and PMA reduce these effects. LIMK1 is therefore a key component of a signal transduction network that connects extracellular stimuli to changes in cytoskeletal structure. Control of cell morphology and mobility via LIMK1 activity may provide novel approaches to cancer therapy. (C) 1999 Elsevier Science Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- PROTEIN-KINASE; ZINC-FINGER; CHROMOSOMAL LOCALIZATION; GENOMIC ORGANIZATION; CDNA CLONING; DOMAINS; GENE; MOTIF; PHOSPHORYLATION; LIM-KINASE-1
- Publisher's Version
- https://doi.org/10.1016/S1357-2725(98)00116-2
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-03-01 12:00:00