The transcriptional regulator Rel is essential for antigen receptor-mediated stimulation of mature T cells but dispensable for positive and negative selection of thymocytes and T cell apoptosis
- Author(s)
- Strasser, A; Grumont, RJ; Stanley, ML; Gerondakis, S;
- Details
- Publication Year 1999-03,Volume 29,Issue #3,Page 928-935
- Journal Title
- EUROPEAN JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The family of Rel/NF-kappa B transcription factors is a crucial regulator of various cellular responses. Using Rel-deficient (c-rel(-/-)) mice crossed with T cell receptor (TCR)-transgenic mice we show that Rel is neither required for positive selection of major histocompatibility complex (MHC)-restricted T cells nor for deletion of thymocytes bearing autoreactive antigen receptors. Our studies also demonstrate that Rel is dispensable for T lymphocyte apoptosis. Rel is, however, essential for antigen-induced activation of mature T cells and its absence exacerbates the anergic state. These results indicate that thymocytes and mature T cells differ in their requirement for Rel in mediating TCR-induced responses.
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- NF-KAPPA-B; PROLIFERATIVE RESPONSES; TARGETED DISRUPTION; TRANSGENIC MICE; DEATH; LACKING; EXPRESSION; LINEAGE; DEFECTS; THYMUS
- Publisher's Version
- https://doi.org/10.1002/(SICI)1521-4141(199903)29:03<928::AID-IMMU928>3.0.CO;2-P
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-03-01 12:00:00