The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
- Author(s)
- Zhang, JG; Farley, A; Nicholson, SE; Willson, TA; Zugaro, LM; Simpson, RJ; Moritz, RL; Cary, D; Richardson, R; Hausmann, G; Kile, BJ; Kent, SBH; Alexander, WS; Metcalf, D; Hilton, DJ; Nicola, NA; Baca, M;
- Details
- Publication Year 1999-03-02,Volume 96,Issue #5,Page 2071-2076
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Publication Type
- Journal Article
- Abstract
- The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors of several cytokine signal transduction pathways. Their expression is induced by cytokine activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway and they act as a negative feedback loop by subsequently inhibiting the JAK/STAT pathway either by direct interaction with activated JAKs or with the receptors, These interactions are mediated at least in part by the SH2 domain of SOCS proteins but these proteins also contain a highly conserved C-terminal homology domain termed the SOCS box. Here we show that the SOCS box mediates interactions with elongins B and C, which in turn may couple SOCS proteins and their substrates to the proteasomal protein degradation pathway. Analogous to the family of F-box-containing proteins, it appears that the SOCS proteins may act as adaptor molecules that target activated cell signaling proteins to the protein degradation pathway.
- Publisher
- NATL ACAD SCIENCES
- Keywords
- INDUCED STAT INHIBITOR; GENE-PRODUCT; FAMILY; SEQUENCES; PEPTIDES
- Publisher's Version
- https://doi.org/10.1073/pnas.96.5.2071
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-03-02 12:00:00