Negative regulation of the JAK/STAT pathway
- Author(s)
- Starr, R; Hilton, DJ;
- Details
- Publication Year 1999-01,Volume 21,Issue #1,Page 47-52
- Journal Title
- BIOESSAYS
- Publication Type
- Journal Article
- Abstract
- Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways, such as the JAK/STAT pathway. Although these responses are generally transient, few molecules have been characterised that switch the signal off. Several different steps of the signal transduction pathway appear to be targeted by negative regulators, including the receptor/ligand complex, JAK kinases, and STAT transcription factors. Negative regulation is achieved by dephosphorylation of signalling intermediates by protein tyrosine phosphatases such as SHP-1, and by proteolytic degradation. Recent studies have identified two new families of negative regulatory molecules, SOCS and PIAS, which function in novel ways to suppress signal transduction pathways, The duration and intensity of a cell's response to cytokine therefore appear to be determined by the net effect of several regulatory mechanisms, (C) 1999 John Wiley a Sons, Inc.
- Publisher
- COMPANY OF BIOLOGISTS LTD
- Keywords
- PROTEIN-TYROSINE-PHOSPHATASE; INDUCED STAT INHIBITOR; SH2 DOMAIN; INTERFERON-GAMMA; SIGNAL-TRANSDUCTION; GENE-EXPRESSION; MOTH-EATEN; RECEPTOR; ACTIVATION; KINASE
- Publisher's Version
- https://doi.org/10.1002/(SICI)1521-1878(199901)21:1<47::AID-BIES6>3.0.CO;2-N
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- Refer to copyright notice on published article.
Creation Date: 1999-01-01 12:00:00