CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells
- Author(s)
- Schofield, L; McConville, MJ; Hansen, D; Campbell, AS; Fraser-Reid, B; Grusby, MJ; Tachado, SD;
- Details
- Publication Year 1999-01-08,Volume 283,Issue #5399,Page 225-229
- Journal Title
- SCIENCE
- Publication Type
- Journal Article
- Abstract
- Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)-restricted recognition of peptide fragments by conventional CD4(+) helper T cells. Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)-anchored protein antigens, however, were found to be regulated in part through CD1d-restricted recognition of the GPI moiety by thymus-dependent, interleukin-4-producing CD4(+), natural killer cell antigen 1.1 [(NK1.1)(+)] helper T cells. The CD1-NKT cell pathway regulated immunogobulin G responses to the GPI-anchored surface antigens of Plasmodium and Trypanosoma and may be a general mechanism for rapid, MHC-unrestricted antibody responses to diverse pathogens.
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Keywords
- PROMPTLY PRODUCE INTERLEUKIN-4; II-DEFICIENT MICE; NK1.1(+) T-CELLS; SIGNAL-TRANSDUCTION; ALPHA-CHAIN; ACTIVATION; CD4(+); CD1; RECOGNITION; LEISHMANIA
- Publisher's Version
- https://doi.org/10.1126/science.283.5399.225
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-01-08 12:00:00