Dr. Josef Steiner Cancer Research Prize Lecture: The role of physiological cell death in neoplastic transformation and in anti-cancer therapy
- Author(s)
- Strasser, A;
- Details
- Publication Year 1999-05-17,Volume 81,Issue #4,Page 505-511
- Journal Title
- INTERNATIONAL JOURNAL OF CANCER
- Publication Type
- Journal Article
- Abstract
- Cell death is a physiological process which is required for normal development and existence of multi-cellular organisms, Physiological cell death, or apoptosis, is controlled by an evolutionarily conserved mechanism, Abnormalities in this process are implicated as a cause or contributing factor in a variety of diseases. Inhibition of apoptosis can promote neoplastic transformation, particularly in combination with dysregulated cell-cycle control, and can influence the response of tumour cells to anti-cancer therapy. Molecular biological and biochemical approaches are used to find missing cell-death regulators and to define signalling cascades, while experiments in genetically modified mice will identify the essential function of these molecules. Discoveries from cell death research should provide clues for designing therapies for a variety of diseases, including degenerative disorders, auto-immunity and cancer. (C) 1999 Wiley-Liss, Inc.
- Publisher
- WILEY-LISS
- Keywords
- ACUTE LYMPHOBLASTIC-LEUKEMIA; SURVIVAL-PROMOTING PROTEINS; RECEPTOR-DEFICIENT MICE; SIGNALING COMPLEX DISC; BCL-2 HOMOLOG BAK; WILD-TYPE P53; TRANSGENIC MICE; T-CELL; C-MYC; CAENORHABDITIS-ELEGANS
- Publisher's Version
- https://doi.org/10.1002/(SICI)1097-0215(19990517)81:4<505::AID-IJC1>3.0.CO;2-J
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-05-17 12:00:00