Differential loss of spinal sensory but not motor neurons in the p75(NTR) knockout mouse

Author(s): Murray, SS; Bartlett, PF; Cheema, SS;
Details: Publication Year 1999-05-21,Volume 267,Issue #1,Page 45-48
Journal Title: NEUROSCIENCE LETTERS
Publication Type: Journal Article
Abstract: Sensory neurons in the dorsal root ganglia (DRG) and motor neurons in the spinal cord express the 75 kDa low-affinity neurotrophin receptor (p75(NTR)) during prenatal development. The p75(NTR) gene knockout mouse provides a unique opportunity to assess the role of p75(NTR) during this period. Quantitative analysis of the p75(NTR) knockout mouse revealed a significant developmental loss of sensory neurons. In the cervico-thoracic ganglia approximately 75% of the neurons are lost, while in the lumbar ganglia the loss is approximately 50%. In contrast, motor neurons were not lost in either the cervical or lumbar spinal cord. These data suggest that p75(NTR) is essential for the prenatal survival of a significant number of sensory, but not motor neurons. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
Publisher: ELSEVIER SCI IRELAND LTD
Keywords: DORSAL-ROOT GANGLIA; NERVOUS-SYSTEM; MICE LACKING; RECEPTOR P75; PC12 CELLS; NGF; DEATH; NEUROTROPHINS; MOTONEURONS; P75(LNTR)
Publisher's Version: https://doi.org/10.1016/S0304-3940(99)00330-4
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1999-05-21 12:00:00