Genetics of host response to malaria
- Author(s)
- Burt, RA;
- Details
- Publication Year 1999-06,Volume 29,Issue #6,Page 973-979
- Journal Title
- INTERNATIONAL JOURNAL FOR PARASITOLOGY
- Publication Type
- Journal Article
- Abstract
- A comprehension of the genetics of host resistance to malaria is essential to understanding the complex host/parasite interaction. Current research is directed towards the genetic dissection of both the murine and human host responses to the disease. Significant progress has been made towards the mapping of novel murine resistance loci. In addition, the role of the major histocompatibility complex in the host response has been examined in both animal models and human populations. Several large segregation analyses, association studies and, more recently, linkage analyses have been conducted in different African populations to examine the role of host genetics in both mild and severe malaria. The results of these studies have been collated within this review. The cloning of genes involved in malarial resistance will lead not only to a greater understanding of this complex disease but, potentially, to the development of effective medical intervention. (C) 1999 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- BLOOD INFECTION LEVELS; RESISTANCE; SUSCEPTIBILITY; PARASITEMIA; 5Q31-Q33; CHILDREN; LINKAGE; COMPLEX; DISEASE; REGION
- Publisher's Version
- https://doi.org/10.1016/S0020-7519(99)00054-5
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-06-01 12:00:00