Transfection of the human malaria parasite Plasmodium falciparum

Author(s): Waterkeyn, JG; Crabb, BS; Cowman, AF;
Details: Publication Year 1999-06,Volume 29,Issue #6,Page 945-955
Journal Title: INTERNATIONAL JOURNAL FOR PARASITOLOGY
Publication Type: Journal Article
Abstract: In the past few years, methods have been developed which allow the introduction of exogenous DNA into the human malaria parasite Plasmodium falciparum. This important technical advance known as parasite transfection, provides powerful new tools to study the function of Plasmodium proteins and their roles in biology and disease. Already it has allowed the analysis of promoter function and has been successfully applied to establish the role of particular molecules and/or mutations in the biology of this parasite. This review summarises the current state of the technology and how it has been applied to dissect the function of the P. falciparum genome. (C) 1999 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Keywords: GREEN FLUORESCENT PROTEIN; TOXOPLASMA-GONDII; STABLE TRANSFECTION; GENE-EXPRESSION; ENTAMOEBA-HISTOLYTICA; BLOOD STAGES; SYNTHASE; TRANSFORMATION; PYRIMETHAMINE; RESISTANCE
Publisher's Version: https://doi.org/10.1016/S0020-7519(99)00047-8
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1999-06-01 12:00:00