CD30 prevents T-cell responses to non-lymphoid tissues
- Author(s)
- Heath, WR; Kurts, C; Caminschi, I; Carbone, FR; Miller, JFAP;
- Journal Title
- IMMUNOLOGICAL REVIEWS
- Publication Type
- Journal Article
- Abstract
- Self antigens can induce T-cell tolerance via a mechanism termed cross-tolerance. This involves the transfer of peripheral tissue antigens to professional APC for presentation in the draining lymph nodes. In this site, CD8(+) T cells are activated, proliferate, and are slowly deleted by a CD95-dependent mechanism. Prior to their deletion, some activated cells leave the lymph nodes and encounter antigens on peripheral parenchymal tissues. Without functional CD30, these cells proliferate extensively and cause substantial tissue damage. Thus, CD30 limits autoreactivity, acting as a 'brake' on T-cell proliferation after recognition of autoantigens on parenchymal tissues.
- Publisher
- MUNKSGAARD INT PUBL LTD
- Keywords
- SELF-ANTIGENS; CROSS-PRESENTATION; TOLERANCE; DELETION; LIGAND; DEATH; APOPTOSIS; RECEPTOR
- Publisher's Version
- https://doi.org/10.1111/j.1600-065X.1999.tb01303.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-06-01 12:00:00