Cytotoxic T lymphocyte activation by cross-priming
- Author(s)
- Heath, WR; Carbone, FR;
- Details
- Publication Year 1999-06,Volume 11,Issue #3,Page 314-318
- Journal Title
- CURRENT OPINION IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Cross-priming represents the induction of cytotoxic T lymphocyte responses to exogenous, usually cell associated, antigens that are captured and re-presented on bone-marrow-derived antigen-presenting cells. For effective cross-priming, cytotoxic T lymphocytes require help from : CD4(+) T cells, which mediate this help indirectly via; modification of the antigen-presenting cell. Recent advances made in research,into the cellular and molecular interactions required for cross-priming have greatly improved our understanding of the antigenic requirements for effective priming and have revealed a role for CD40 and its ligand in the provision of T cell help.
- Publisher
- CURRENT BIOLOGY LTD
- Keywords
- CLASS-I PRESENTATION; CD40-CD40 LIGAND INTERACTION; EXOGENOUS SOLUBLE-ANTIGEN; MINOR H-ANTIGENS; DENDRITIC CELLS; SELF-ANTIGENS; CD40 LIGAND; ENDOPLASMIC-RETICULUM; PRESENTING CELLS; APOPTOTIC CELLS
- Publisher's Version
- https://doi.org/10.1016/S0952-7915(99)80050-8
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-06-01 12:00:00