The Charlotte Friend Memorial Lecture. The role of hematopoietic growth factors in the development and suppression of myeloid leukemias
- Author(s)
- Metcalf, D;
- Journal Title
- LEUKEMIA
- Publication Type
- Journal Article
- Abstract
- The transformation of normal hematopoietic cells to leukemic cells requires cells to acquire two intrinsic changes. These are the acquisition by some method of autocrine growth stimulation and a perturbation of differentiation commitment leading to abnormal levels of self-generation. Hematopoietic regulator action can be involved to produce or facilitate both these changes but the same regulators can also suppress some leukemic populations by enforced differentiation commitment.
- Publisher
- STOCKTON PRESS
- Keywords
- COLONY-STIMULATING FACTOR; ACUTE MYELOBLASTIC-LEUKEMIA; IRRADIATED RECIPIENT MICE; FACTOR-DEPENDENT CELLS; HOX-2.4 HOMEOBOX GENE; GM-CSF; CLONAL ANALYSIS; MYELOPROLIFERATIVE SYNDROME; ERYTHROPOIETIN RECEPTOR; AUTONOMOUS GROWTH
- Publisher's Version
- https://doi.org/10.1038/sj.leu.2401376
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-04-01 12:00:00