Nerve growth factor modulates myelin-associated glycoprotein binding to sensory neurons
- Author(s)
- Turnley, AM; Bartlett, PF;
- Details
- Publication Year 1999-04,Volume 17,Issue #2,Page 109-119
- Journal Title
- INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
- Publication Type
- Journal Article
- Abstract
- Myelin-associated glycoprotein (MAG) is a molecule expressed by myelinating cells at the myelin/axon interface, which binds to an as yet unidentified molecule on neurons. We have used a MAG-immunoglobulin Fe fusion protein to examine the expression and regulation of the MAG binding molecule on sensory neurons in culture. Binding of the MAG Fe reached a maximum at 24-48 h and was higher on neurons which expressed high levels of neurofilament. Nerve growth factor (SGF) upregulated expression of the MAG binding molecule in a dose dependent manner. Schwann cells co-cultured with sensory neurons in serum-free medium stimulated maximal expression of the MAG binding molecule, which was decreased by addition of anti-NGF to the co-cultures. This indicated that Schwann cells can modulate expression of the MAG binding molecule via production of NGF and may represent a physiological mechanism for regulation of MAG-MAG binding molecule interactions during myelination and remyelination. (C) 1999 ISDN. Published by Elsevier Science Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- LEUKEMIA INHIBITORY FACTOR; NEUROFILAMENT GENE-EXPRESSION; SCHWANN-CELLS; AXONAL REGENERATION; NEURITE OUTGROWTH; PERIPHERAL-NERVE; MICE DEFICIENT; SCIATIC-NERVE; UP-REGULATION; MAJOR MYELIN
- Publisher's Version
- https://doi.org/10.1016/S0736-5748(98)00068-9
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-04-01 12:00:00