FADD/MORT1, a signal transducer that can promote cell death or cell growth
- Author(s)
- Strasser, A; Newton, K;
- Details
- Publication Year 1999-05,Volume 31,Issue #5,Page 533-537
- Journal Title
- INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- FADD/MORT1 is a cytosolic adaptor protein which is critical for signalling from CD95 (Fas/APO-1) and certain other members of the tumour necrosis factor receptor (TNF-R) family (called 'death receptors'). Two protein interaction domains have been identified in FADD/MORT1. The C-terminal 'death domain is needed for recruitment of FADD/MORT1 to ligated 'death receptors' and the N-terminal 'death effector domain' mediates oligomerisation and activation of caspase-8 zymogens. Caspase-8 activates other cysteine proteases by cleavage and this starts a proteolytic cascade which constitutes the 'point of no return' in apoptosis signalling. Experiments in mice lacking FADD/MORT1 function proved that this adaptor is required for CD95- and TNF-RI-transduced cell death but is dispensable for other pathways to apoptosis. Surprisingly, FADD/MORT1 is also essential for mitogen-induced proliferation of T-lymphocytes. Therapeutic activation of FADD/MORT1 Function may be used to kill unwanted cells in cancer or autoimmunity and its suppression may help prevent cell death in certain degenerative disorders. (C) 1999 Elsevier Science Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- LYMPHOCYTE APOPTOSIS; NMR STRUCTURE; FADD; DOMAIN; PROTEIN; FAS; MUTAGENESIS; INTERACTS; RECEPTOR; FAS/APO1
- Publisher's Version
- https://doi.org/10.1016/S1357-2725(99)00003-5
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-05-01 12:00:00