The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1

Author(s): Reeder, JC; Cowman, AF; Davern, KM; Beeson, JG; Thompson, JK; Rogerson, SJ; Brown, GV;
Details: Publication Year 1999-04-27,Volume 96,Issue #9,Page 5198-5202
Journal Title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publication Type: Journal Article
Abstract: Chondroitin sulfate A (CSA) is an important receptor for the sequestration of Plasmodium falciparum in the placenta, but the parasite ligand involved in adhesion has not previously been identified. Here we report the identification of a var gene transcribed in association with binding to CSA and present evidence that the P. falciparum erythrocyte membrane protein 1 product of the gene is the parasite ligand mediating CSA binding. Description of this gene and the implication of P. falciparum erythrocyte membrane protein 1 as the parasite ligand paves the way to a more detailed understanding of the pathogenesis of placental infection and potential therapeutic strategies targeting the interaction.
Publisher: NATL ACAD SCIENCES
Keywords: MICROVASCULAR ENDOTHELIAL-CELLS; ANTIGENIC VARIATION; FLOW CONDITIONS; VAR GENES; MALARIA; RECEPTOR; CYTOADHERENCE; ADHERENCE; EXPRESSION; IDENTIFICATION
Publisher's Version: https://doi.org/10.1073/pnas.96.9.5198
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1999-04-27 12:00:00