CONSTITUTIVE EXPRESSION OF THE PUTATIVE TRANSCRIPTION FACTOR SCL ASSOCIATED WITH PROVIRAL INSERTION IN THE MYELOID LEUKEMIC-CELL LINE WEHI-3BD(-1)
- Author(s)
- TANIGAWA, T; Robb, L; Green, AR; Begley, CG;
- Details
- Publication Year 1994-06,Volume 5,Issue #6,Page 557-561
- Journal Title
- CELL GROWTH & DIFFERENTIATION
- Publication Type
- Journal Article
- Abstract
- The murine myeloid leukemia WEHI-3B contains an intracisternal A-particle insertion in a growth factor gene (IL-3) and a homeobox gene (Hox 2.4). Southern blot analysis of the differentiation unresponsive subline WEHI-3BD- demonstrated a rearrangement of the SCL gene, a gene that encodes a protein of the helix-loop-helix class of transcription factors. Northern blot analysis demonstrated an abnormal SCL transcript in the WEHI-3BD- cells, although SCL expression was not detected in the parental cells. The rearrangement was cloned and confirmed as an insertion of an intracisternal A-particle in the 3' untranslated region of the SCL gene. Although SCL is implicated in up to 25% of human T-cell acute lymphoblastic leukemia, this is the first example of SCL involvement in a myeloid leukemia.
- Publisher
- AMER ASSOC CANCER RESEARCH
- Keywords
- INTRACISTERNAL-A-PARTICLE; HEMATOPOIETIC-CELLS; HOMEOBOX GENE; DNA-BINDING; ERYTHROID-DIFFERENTIATION; REARRANGEMENT; TRANSFORMATION; INTERLEUKIN-3; TRANSPOSITION; TRANSLOCATION
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Creation Date: 1994-06-01 12:00:00