NEURONAL PROGENITORS IDENTIFIED BY THEIR INABILITY TO EXPRESS CLASS-I HISTOCOMPATIBILITY ANTIGENS IN RESPONSE TO INTERFERON-GAMMA

Author(s): BAILEY, KA; DRAGO, J; Bartlett, PF;
Details: Publication Year 1994-10-01,Volume 39,Issue #2,Page 166-177
Journal Title: JOURNAL OF NEUROSCIENCE RESEARCH
Publication Type: Journal Article
Abstract: Interferon-gamma (IFN-gamma) can induce class I major histocompatibility complex (MHC) antigen (H-2) expression on virtually all neuroepithelial cells isolated from embryonic day 9 (E9) mice. However, a subpopulation of cells become refractory to H-2 induction (H-21(-)) by E10 and the percentage of H-2 noninducible cells increases during development. Cell sorting, by flow cytometry or magnetic bead immunoselection, has shown that H-21(-) cells give rise exclusively to neuronal cells, and by E12, the majority of the neuronal progenitors are found within this population. It has also been found that 98% of the H-21(-) also express the neuron-associated marker, A2B5. Cells of the glial cell lineage retain the ability to express class I antigens throughout development. From these studies, it is clear that the neuroepithelium contains cells committed to the neuronal cell lineage as early as E10 in the mouse. (C) 1994 Wiley-Liss, Inc.
Publisher: WILEY-LISS
Keywords: CELL-SURFACE ANTIGEN; MONOCLONAL-ANTIBODIES; EPENDYMAL CELLS; NERVOUS-SYSTEM; GLIAL-CELLS; BRAIN-CELLS; PROTEIN; RAT; OLIGODENDROCYTES; DIFFERENTIATION
Publisher's Version: https://doi.org/10.1002/jnr.490390207
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1994-10-01 12:00:00