NOVEL FEATURES OF THE RESPIRATORY-TRACT T-CELL RESPONSE TO INFLUENZA-VIRUS INFECTION - LUNG T-CELLS INCREASE EXPRESSION OF GAMMA-INTERFERON MESSENGER-RNA IN-VIVO AND MAINTAIN HIGH-LEVELS OF MESSENGER-RNA EXPRESSION FOR INTERLEUKIN-5 (IL-5) AND IL-10
- Author(s)
- BAUMGARTH, N; BROWN, L; Jackson, D; Kelso, A;
- Details
- Publication Year 1994-11,Volume 68,Issue #11,Page 7575-7581
- Journal Title
- JOURNAL OF VIROLOGY
- Publication Type
- Journal Article
- Abstract
- Analysis of the respiratory tract before and after primary influenza virus infection revealed a virus-induced preferential accumulation of a CD8(+) T-cell population that coexpresses mRNA for interleukin-5 (IL-5) and IL-10 with virus dose dependent high levels of gamma interferon. However, cytokine production in lung tissues was not restricted to the T-cell population, since CD3(-) cells were found to express mRNA for various cytokines, including IL-4 and particularly IL-6 and granulocyte-macrophage colony-stimulating factor. These data provide in vivo evidence for a local respiratory tract immune response to influenza virus infection dominated by cytokine-producing CD8(+) T cells.
- Publisher
- AMER SOC MICROBIOLOGY
- Keywords
- IFN-GAMMA; TH2 CELLS; A VIRUS; MICE; CD4+; IMMUNITY; ACTIVATION; CLEARANCE; PNEUMONIA; FREQUENCY
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Creation Date: 1994-11-01 12:00:00