B-LYMPHOID TO GRANULOCYTIC SWITCH DURING HEMATOPOIESIS IN A TRANSGENIC MOUSE STRAIN
- Author(s)
- Lindeman, GJ; Adams, JM; Cory, S; Harris, AW;
- Details
- Publication Year 1994-09,Volume 1,Issue #6,Page 517-527
- Journal Title
- IMMUNITY
- Publication Type
- Journal Article
- Abstract
- B-lymphoid and myeloid development are markedly perturbed in a unique transgenic mouse strain, max 41. Pro-B, pre-B, and B lymphocytes were severely reduced but granulocytes were greatly elevated. This phenotype could be adoptively transferred with bone marrow cells. It was not alleviated by bcl-2 or myc transgenes that promote lymphocyte survival or proliferation. Bitransgenic myc/max 41 mice developed pre-B cell lymphoma. An accompanying massive granulocytosis unexpectedly proved to be clonally derived from the pre-B lymphoma cells. These observations suggest that B lymphopoiesis in max 41 mice has been diverted to granulocyte production. Since neither cell type expressed the transgene, this novel lymphomyeloid deviation probably reflects insertional alteration of a hematopoietic regulatory gene.
- Publisher
- CELL PRESS
- Keywords
- COLONY-STIMULATING FACTOR; HELIX-ZIPPER PROTEIN; CELLS-INVITRO; SCID MICE; GENE; MYC; DIFFERENTIATION; EXPRESSION; POPULATION; LEUKEMIA
- Publisher's Version
- https://doi.org/10.1016/1074-7613(94)90094-9
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1994-09-01 12:00:00