LOCALIZATION OF A HUMAN RECEPTOR TYROSINE KINASE (ETK1) TO CHROMOSOME REGION 3P11.2
- Author(s)
- Wicks, IP; LAPSYS, NM; Baker, E; Campbell, LJ; Boyd, AW; Sutherland, GR;
- Details
- Publication Year 1994-01-01,Volume 19,Issue #1,Page 38-41
- Journal Title
- GENOMICS
- Publication Type
- Journal Article
- Abstract
- We have recently described a human receptor tyrosine kinase (hek) that is expressed by some pre-B and thymic T cell lines, but is not detectable on normal adult human tissues. Gene cloning studies established that hek is a new member of the EPH family of receptor tyrosine kinases. The expression of hek may normally be developmentally regulated and inappropriate expression may contribute to oncogenesis. In the present study, we have used Southern blot analysis of somatic cell hybrids and fluorescence in situ hybridization to localize the hek gene to human chromosome region 3p11.2. Karyotype analysis of the cell lines that overexpress hek showed no cytogenetically visible abnormality involving the hek locus. (C) 1994 Academic Press, Inc.
- Publisher
- ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
- Keywords
- CELL LINES; EPH GENE; IDENTIFICATION; CLONING; CHICKEN; FAMILY; MOUSE; 3P21; HEK; ELK
- Publisher's Version
- https://doi.org/10.1006/geno.1994.1009
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1994-01-01 12:00:00