REGULATION OF THE EARLY DEVELOPMENT OF THE NERVOUS-SYSTEM BY GROWTH-FACTORS
- Author(s)
- Bartlett, PF; Kilpatrick, TJ; Richards, LJ; TALMAN, PS; Murphy, M;
- Details
- Publication Year 1994,Volume 64,Issue #3,Page 371-393
- Journal Title
- PHARMACOLOGY & THERAPEUTICS
- Publication Type
- Journal Article
- Abstract
- Development of the nervous system, although patterned by intrinsic genetic expression, appears to be dependent on growth factors for many of the differentiation steps that generate the wide variety of neurons and glia found in the both the central and peripheral nervous system. By using in vitro assays, including clonal analysis, the precise function of the various growth factors and the differentiation potential of the various neural populations has begun to be described. This review discusses some of the recent findings and examines how neuronal differentiation may result from the interaction of several growth factors.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- NEURAL CREST CELLS; LEUKEMIA-INHIBITORY FACTOR; CILIARY NEUROTROPHIC FACTOR; GLIAL PROGENITOR-CELL; RAT OPTIC-NERVE; TYPE-2 ASTROCYTE DEVELOPMENT; FACTOR STIMULATES SURVIVAL; TYROSINE KINASE RECEPTOR; CLONALLY RELATED CELLS; MEDIATED GENE-TRANSFER
- Publisher's Version
- https://doi.org/10.1016/0163-7258(94)00044-1
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1994-01-01 12:00:00