COLOCALIZATION OF FGF-2 AND A NOVEL HEPARAN-SULFATE PROTEOGLYCAN IN EMBRYONIC MOUSE-BRAIN
- Author(s)
- Ford, MD; Bartlett, PF; Nurcombe, V;
- Details
- Publication Year 1994-01-31,Volume 5,Issue #5,Page 565-568
- Journal Title
- NEUROREPORT
- Publication Type
- Journal Article
- Abstract
- NEURAL precursor cells are known to be greatly stimulated during their development by members of the fibroblast growth factor (FGF) family of growth factors. FGF activity is regulated by essential interactions with a low affinity class of receptors called heparan sulphate proteoglycans (HSPGs), which modulate subsequent binding to the high affinity signal transducing receptors. We have purified a novel species of secreted HSPG and generated specific polyclonal antibodies against its core protein. The HSPG exactly co-localizes with FGF-2 within the neuroepithelium of the embryonic mouse. The results support the concept that HSPGs play crucial roles in regulating neural cell responses to particular growth factors.
- Publisher
- RAPID SCIENCE PUBLISHERS
- Keywords
- FIBROBLAST GROWTH-FACTOR; NEURAL PRECURSOR CELLS; ADHESION MOLECULE; SULFATE; DIFFERENTIATION; STIMULATION; BINDING
- Publisher's Version
- https://doi.org/10.1097/00001756-199401000-00008
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1994-01-31 12:00:00