LEUKEMIA INHIBITORY FACTOR RESCUES MOTONEURONS FROM AXOTOMY-INDUCED CELL-DEATH
- Author(s)
- Cheema, SS; Richards, LJ; Murphy, M; Bartlett, PF;
- Details
- Publication Year 1994-04-14,Volume 5,Issue #8,Page 989-992
- Journal Title
- NEUROREPORT
- Publication Type
- Journal Article
- Abstract
- THE death of spinal motoneurones after axotomy provides a useful model for studying novel factors which prevent motoneurone loss in vivo. Peripheral nerves of newborn rats were unilaterally transected and treated with either a vehicle solution or leukaemia inhibitory factor (LIF). Compared with the vehicle controls, treatment with a gelfoam containing LIF significantly reduced motoneurone loss: from 38% to 22% after 3 days and from 55% to 38% after 7 days. The loss of motoneurones was further reduced by placing the LIF-containing gelfoam inside a silicone chamber: from 39% to 15% after 7 days, which represented a 62% rescue. Thus, LIF is a potential therapeutic agent for preventing the loss of injured or diseased motoneurones.
- Publisher
- RAPID SCIENCE PUBLISHERS
- Keywords
- MOTOR NEURONS; PROMOTES
- Publisher's Version
- https://doi.org/10.1097/00001756-199404000-00034
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1994-04-14 12:00:00