THE MODE OF ACTION AND THE MECHANISM OF RESISTANCE TO ANTIMALARIAL-DRUGS
- Author(s)
- Foote, SJ; Cowman, AF;
- Details
- Publication Year 1994-03,Volume 56,Issue #2-3,Page 157-171
- Journal Title
- ACTA TROPICA
- Publication Type
- Journal Article
- Abstract
- The mechanism of action of the antifolate and quinoline antinialarials has been investigated over the last few decades, and recent advances should aid the development of new drugs to combat the increasingly refractile parasite. The molecular description of resistance to the antifolates has been well characterised and is due to structural changes in the target enzymes, but the factors involved in the parasite's ability to circumvent the action of the quinoline antimalarials have yet to be fully elucidated. This review discusses the mode of action of these drugs and the means used by the parasite to defeat our therapeutic ingenuity.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- REDUCTASE-THYMIDYLATE SYNTHASE; ALTERED DIHYDROFOLATE-REDUCTASE; PARASITE PLASMODIUM-FALCIPARUM; INFECTED HUMAN-ERYTHROCYTES; X-RAY STRUCTURE; CHLOROQUINE-RESISTANCE; PYRIMETHAMINE RESISTANCE; FERRIPROTOPORPHYRIN-IX; MALARIA PARASITES; MEFLOQUINE RESISTANCE
- Publisher's Version
- https://doi.org/10.1016/0001-706X(94)90061-2
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1994-03-01 12:00:00