CYTOKINE INDUCTION OF ADHESION MOLECULES ON SYNOVIAL TYPE-B CELLS
- Author(s)
- CICUTTINI, FM; Martin, M; Boyd, AW;
- Details
- Publication Year 1994-03,Volume 21,Issue #3,Page 406-412
- Journal Title
- JOURNAL OF RHEUMATOLOGY
- Publication Type
- Journal Article
- Abstract
- Objectives. To study the role of cytokines on adhesion molecule expression and binding of activated T cells to synovial type B cells. Methods. Adhesion molecule expression was examined by immunofluorescence and adhesion of Cr-51-labelled T cells to the synovial cells determined. Results. Tumor necrosis factor alpha/interferon gamma (TNF alpha/IFN-gamma) and interleukin 1 alpha (IL-1 alpha)/IFN-gamma enhanced adhesion molecule expression and the adhesion of T cells to synovial cells. Anti-intercellular adhesion molecule 1 blocked adhesion of T cells to TNF alpha/IFN-gamma and IL-1 alpha/IFN-gamma stimulated synovial cells while an antibody to CD61 blocked adhesion to IL-1 alpha/IFN-gamma stimulated cells. Conclusions. The interaction of leukocytes with adhesion molecules on synovial cells may play a role in recruitment of these cells to an inflammatory site.
- Publisher
- J RHEUMATOL PUBL CO
- Keywords
- CHRONIC INFLAMMATORY ARTHRITIS; FIBROBLAST-LIKE SYNOVIOCYTES; COLONY-STIMULATING FACTOR; RHEUMATOID-ARTHRITIS; T-CELLS; INTERLEUKIN-2 PRODUCTION; EXTRACELLULAR-MATRIX; FIBRONECTIN RECEPTOR; VITRONECTIN RECEPTOR; MONONUCLEAR-CELLS
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- Refer to copyright notice on published article.
Creation Date: 1994-03-01 12:00:00