OCT-2 IS REQUIRED EARLY IN T-CELL-INDEPENDENT B-CELL ACTIVATION FOR G1 PROGRESSION AND FOR PROLIFERATION
- Author(s)
- Corcoran, LM; KARVELAS, M;
- Details
- Publication Year 1994-11,Volume 1,Issue #8,Page 635-645
- Journal Title
- IMMUNITY
- Publication Type
- Journal Article
- Abstract
- Oct-2, a POU homeodomain protein expressed primarily in B cells, is a powerful transcriptional activator that binds to DNA at sites appropriately placed for major effects on immunoglobulin gene expression. Our examination of B cell development and function in Oct-2 null mice did not support an essential role for Oct-2 early in B cell development. Rather, Oct-2 was required later, when B cells were induced to differentiate to antibody-secreting cells. We show here that Oct-2 is not required for normal immunoglobulin production by mature B lymphocytes. Instead, it is essential for a normal proliferative response to polyclonal mitogens. Responses to signals from activated T cells are unaffected. The requirement for Oct-2 maps to an early activation step in G1, during which B cells make the commitment to progress through the cell cycle and to divide.
- Publisher
- CELL PRESS
- Keywords
- REMOTE ENHANCER POSITION; OCTAMER DNA MOTIF; TRANSCRIPTION FACTOR; PROTEIN-BINDING; LYMPHOCYTES-B; IMMUNOGLOBULIN PROMOTERS; SURFACE-IMMUNOGLOBULIN; TRANSGENIC MICE; GENE; EXPRESSION
- Publisher's Version
- https://doi.org/10.1016/1074-7613(94)90035-3
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1994-11-01 12:00:00