OVEREXPRESSED MAX IS NOT ONCOGENIC AND ATTENUATES MYC-INDUCED LYMPHOPROLIFERATION AND LYMPHOMAGENESIS IN TRANSGENIC MICE
- Author(s)
- Lindeman, GJ; Harris, AW; Bath, ML; EISENMAN, RN; Adams, JM;
- Details
- Publication Year 1995-03-02,Volume 10,Issue #5,Page 1013-1017
- Journal Title
- ONCOGENE
- Publication Type
- Journal Article
- Abstract
- The cellular growth promoting function of the Myc oncoprotein requires its heterodimerization with the Max protein, but Max can also form complexes that inhibit Myc action. To determine whether man overexpression in vivo is oncogenic and whether it can modulate the action of Myc, we generated transgenic mice in which the max gene was directed to express in lymphoid cells by a linked immunoglobulin heavy chain enhancer (E mu). Expression of the transgene at substantially higher levels than the endogenous max gene did not perturb lymphoid homeostasis in adult animals nor predispose to lymphomagenesis. The numbers of B-lymphoid cells in very young animals were reduced. Moreover, analysis of bi-transgenic E mu-myc/E mu-max mice revealed that man overexpression attenuated the premalignant B-lymphoproliferative state induced by an Ep-myr: transgene and reduced the rate of lymphoma onset. These results suggest that elevation of Max expression in vivo inhibits the function of Myc.
- Publisher
- STOCKTON PRESS
- Keywords
- C-MYC; DNA-BINDING; PROTEIN; GENE; COTRANSFORMATION; TRANSCRIPTION; DIMERIZATION; ACTIVATION; EXPRESSION; LEUKEMIA
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1995-03-02 12:00:00