ROLE OF INTERLEUKIN-6 IN T-CELL ACTIVATION DURING PRIMARY AND SECONDARY INFECTION WITH LISTERIA-MONOCYTOGENES
- Author(s)
- Liu, ZQ; Simpson, RJ; Cheers, C;
- Details
- Publication Year 1995-07,Volume 63,Issue #7,Page 2790-2792
- Journal Title
- INFECTION AND IMMUNITY
- Publication Type
- Journal Article
- Abstract
- Injection of recombinant interleukin-6 (IL-6) into mice enhances recovery from infection with Listeria monocytogenes. Ln this study, the role of IL-6 during primary and secondary Listeria infection was further tested. Neutralization of IL-6 by polyclonal antibody exacerbated primary infection and significantly delayed gamma interferon production by cultured spleen cells. Fn contrast, administration of anti-IL-6 antibody at the time of secondary infection did not affect the recovery of mice from infection or gamma interferon production, showing that activated T cells are not dependent on IL-6.
- Publisher
- AMER SOC MICROBIOLOGY
- Keywords
- INTERFERON-GAMMA PRODUCTION; TUMOR NECROSIS FACTOR; BACTERIAL-INFECTION; MICE; RESISTANCE
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1995-07-01 12:00:00