EXPRESSION OF 2 T-CELL RECEPTOR-ALPHA CHAINS ON THE SURFACE OF NORMAL MURINE T-CELLS
- Author(s)
- Heath, WR; Carbone, FR; Bertolino, P; Kelly, J; COSE, S; Miller, JFAP;
- Details
- Publication Year 1995-06,Volume 25,Issue #6,Page 1617-1623
- Journal Title
- EUROPEAN JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- We have previously reported that a subset of T cells in T cell receptor (TCR)-transgenic mice may express two different a chains on their surface. The expression of two functional a chains has also been demonstrated for human peripheral blood T cells. In this report, we show that a proportion of normal murine lymph node T cells express two functional a chains on their surface. The extrapolated frequency of these cells present in the normal repertoire ranges from 7-21 %, with an average of 15 %. Our analysis of a small number of antigen-specific T cell clones suggests that the frequency of antigen-responsive cells expressing two surface a chains is relatively low. This raises the possibility that dual a chain T cells may have a selective disadvantage in responding to specific antigen.
- Publisher
- VCH PUBLISHERS INC
- Keywords
- TOXIC LYMPHOCYTES-T; TRANSGENIC MICE; DEPENDENT RECOGNITION; MONOCLONAL-ANTIBODY; ALLELIC EXCLUSION; TCR-BETA; GENES; THYMOCYTES; REARRANGEMENTS; HETERODIMER
- Publisher's Version
- https://doi.org/10.1002/eji.1830250622
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1995-06-01 12:00:00