TARGETED DISRUPTION OF THE LOW-AFFINITY LEUKEMIA INHIBITORY FACTOR-RECEPTOR GENE CAUSES PLACENTAL, SKELETAL, NEURAL AND METABOLIC DEFECTS AND RESULTS IN PERINATAL DEATH
- Author(s)
- Ware, CB; HOROWITZ, MC; RENSHAW, BR; HUNT, JS; LIGGITT, D; Koblar, SA; GLINIAK, BC; McKenna, HJ; PAPAYANNOPOULOU, T; THOMA, B; CHENG, LZ; DONOVAN, PJ; Peschon, JJ; Bartlett, PF; WILLIS, CR; WRIGHT, BD; CARPENTER, MK; DAVISON, BL; Gearing, DP;
- Details
- Publication Year 1995-05,Volume 121,Issue #5,Page 1283-1299
- Journal Title
- DEVELOPMENT
- Publication Type
- Journal Article
- Abstract
- The low-affinity receptor for leukemia inhibitory factor (LIFR)* interacts with gp130 to induce an intracellular signal cascade, The LIFR-gp130 heterodimer is implicated in the function of diverse systems, Normal placentation is disrupted in LIFR mutant animals, which leads to poor intrauterine nutrition but allows fetuses to continue to term. Fetal bone volume is reduced greater than three-fold and the number of osteoclasts is increased six-fold, resulting in severe osteopenia of perinatal bone. Astrocyte numbers are reduced in the spinal cord and brain stem. Late gestation fetal livers contain relatively high stores of glycogen, indicating a metabolic disorder. Hematologic and primordial germ cell compartments appear normal. Pleiotropic defects in the mutant animals preclude survival beyond the day of birth.
- Publisher
- COMPANY OF BIOLOGISTS LTD
- Keywords
- PRIMORDIAL GERM-CELLS; HEMATOPOIETIC STEM-CELLS; NEURONAL DIFFERENTIATION FACTOR; IL-6 SIGNAL TRANSDUCER; GROWTH-FACTOR; CONDITIONED MEDIUM; HUMAN INTERLEUKIN; SENSORY NEURONS; FACTOR LIF; DA CELLS
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1995-05-01 12:00:00