MOUSE THYMUS DENDRITIC CELLS - KINETICS OF DEVELOPMENT AND CHANGES IN SURFACE-MARKERS DURING MATURATION
- Author(s)
- Wu, L; Vremec, D; ARDAVIN, C; Winkel, K; Suss, G; GEORGIOU, H; Maraskovsky, E; Cook, W; Shortman, K;
- Details
- Publication Year 1995-02,Volume 25,Issue #2,Page 418-425
- Journal Title
- EUROPEAN JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The early thymus precursor population of adult mice has the capacity to generate T cells, B cells and dendritic cells (DC). These precursors were injected into the thymus of irradiated recipients in order to follow the kinetics of thymic DC development. The resultant cohort of T-lineage cells developing in the thymus was accompanied by a parallel cohort of DC, present at 10(3)-fold lower frequency. The intrathymic lifespan of these DC was as short as that of T-lineage thymocytes. As the thymic DC matured, some markers characteristic of the original precursor population gradually declined (Ly-5, c-kit, Sca-2) whereas markers characteristic of thymic DC appeared and were maintained (major histocompatibility complex class II, CD11c, NLDC-145 and CD8 alpha). Some thymic DC expressed the early B-cell marker BP-1, and BP-1 mRNA, throughout their maturation. The surface markers on thymic DC could be divided into two groups. Some markers, including class I and class II MHC, CD8 alpha and BP-1, appeared to be integral components of the DC surface. In contrast, other markers, including Thy-1, CD4 and CD8 beta, had probably been picked up from associated thymocytes.
- Publisher
- VCH PUBLISHERS INC
- Keywords
- TRANSFORMATION-ASSOCIATED ANTIGEN; LANGERHANS CELLS; PRECURSOR CELLS; EXPRESSION; DISTINCT; MOLECULE; RECEPTOR; SPLEEN; MHC
- Publisher's Version
- https://doi.org/10.1002/eji.1830250217
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1995-02-01 12:00:00