BCL-2 INCREASES MEMORY B-CELL RECRUITMENT BUT DOES NOT PERTURB SELECTION IN GERMINAL-CENTERS
- Author(s)
- Smith, KGC; WEISS, U; RAJEWSKY, K; Nossal, GJV; Tarlinton, DM;
- Details
- Publication Year 1994-12,Volume 1,Issue #9,Page 803-813
- Journal Title
- IMMUNITY
- Publication Type
- Journal Article
- Abstract
- To address the role of apoptosis in the humoral immune response, we have examined a well-characterized T cell-dependent B cell response in mice expressing transgenic Bcl-2 in their B lymphocytes. The selection of somatic mutants and the appearance of high affinity antibodies was not affected by constitutive Bcl-2 expression. Such expression did, however, disproportionately increase the antigen-specific memory B cell pool, suggesting that the final size of the memory compartment may be regulated by an apoptotic process, which, in turn, can be influenced by Bcl-2. In addition, transgenic mice showed prolonged survival of foci of early antibody-producing cells, suggesting their removal is mediated by apoptosis that can be blocked by Bcl-2.
- Publisher
- CELL PRESS
- Keywords
- PRIMARY IMMUNE-RESPONSE; MOLECULAR CHARACTERIZATION; PRIMARY IMMUNIZATION; AFFINITY MATURATION; ANTIBODY-RESPONSES; TRANSGENIC MICE; DEATH; ANTIGEN; APOPTOSIS; PROTEIN
- Publisher's Version
- https://doi.org/10.1016/S1074-7613(94)80022-7
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1994-12-01 12:00:00