T-CELL TOLERANCE AND AUTOIMMUNITY IN TRANSGENIC MODELS OF CENTRAL AND PERIPHERAL TOLERANCE
Details
Publication Year 1994-12, Volume 6, Issue #6, Page 892-899
Journal Title
CURRENT OPINION IN IMMUNOLOGY
Publication Type
Journal Article
Abstract
Experiments with transgenic mice expressing genes encoding both antigens in defined tissues and T-cell receptor genes of known specificities have enhanced our understanding of the mechanisms involved in the pathogenesis of autoimmune states. They have also shed light on the means by which potentially autoreactive cells may be prevented from exerting their autoaggressive potential. The value of the transgenic approach is that it can overcome the low frequency of peptide-specific T cells occurring in normal animals, and also provide a tissue-specific, cognate antigen that is absent in controls. These factors allow reactive T cells to be isolated or quantified by flow cytometry and their responses to antigen in vitro and in vivo be defined.
Publisher
CURRENT BIOLOGY LTD
Keywords
NONOBESE DIABETIC MICE; THYMIC MEDULLARY EPITHELIUM; ANTIGEN-PRESENTING CELLS; NECROSIS-FACTOR-ALPHA; NEGATIVE SELECTION; POSITIVE SELECTION; CLONAL DELETION; BETA-CHAIN; EXPRESSION; THYMOCYTES
Rights Notice
Refer to copyright notice on published article.


Creation Date: 1994-12-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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