T-CELL TOLERANCE AND AUTOIMMUNITY IN TRANSGENIC MODELS OF CENTRAL AND PERIPHERAL TOLERANCE
- Author(s)
- Miller, JFAP; Flavell, RA;
- Details
- Publication Year 1994-12,Volume 6,Issue #6,Page 892-899
- Journal Title
- CURRENT OPINION IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Experiments with transgenic mice expressing genes encoding both antigens in defined tissues and T-cell receptor genes of known specificities have enhanced our understanding of the mechanisms involved in the pathogenesis of autoimmune states. They have also shed light on the means by which potentially autoreactive cells may be prevented from exerting their autoaggressive potential. The value of the transgenic approach is that it can overcome the low frequency of peptide-specific T cells occurring in normal animals, and also provide a tissue-specific, cognate antigen that is absent in controls. These factors allow reactive T cells to be isolated or quantified by flow cytometry and their responses to antigen in vitro and in vivo be defined.
- Publisher
- CURRENT BIOLOGY LTD
- Keywords
- NONOBESE DIABETIC MICE; THYMIC MEDULLARY EPITHELIUM; ANTIGEN-PRESENTING CELLS; NECROSIS-FACTOR-ALPHA; NEGATIVE SELECTION; POSITIVE SELECTION; CLONAL DELETION; BETA-CHAIN; EXPRESSION; THYMOCYTES
- Publisher's Version
- https://doi.org/10.1016/0952-7915(94)90010-8
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1994-12-01 12:00:00