LEUKEMIA INHIBITORY FACTOR - ASSOCIATION WITH INTRAAMNIOTIC INFECTION
- Author(s)
- Waring, PM; ROMERO, R; LAHAM, N; GOMEZ, R; RICE, GE;
- Details
- Publication Year 1994-11,Volume 171,Issue #5,Page 1335-1341
- Journal Title
- AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Publication Type
- Journal Article
- Abstract
- OBJECTIVE: Our purpose was to investigate whether leukemia inhibitory factor is associated with intraamniotic infection. STUDY DESIGN: A comparative clinical study of amniotic fluid leukemia inhibitory factor concentrations was performed. RESULTS: Leukemia inhibitory factor was undetectable (<1 ng/ml) by radioreceptor assay during normal pregnancy at midtrimester and at term. Among women in labor those with intraamniotic infection had higher leukemia factor concentrations than those without infection before term (p < 0.001) and at term (p < 0.005). The leukemia inhibitory factor concentrations correlated with the amniotic fluid white blood cell counts (r = 0.47) (p < 0.001). In cultured human gestational tissue explants, leukemia inhibitory factor release was significantly enhanced by endotoxin, interleukin-1 alpha, and tumor necrosis factor-alpha however, leukemia inhibitory factor did not enhance the release of prostaglandin E(2) by these tissues. CONCLUSIONS: Amniotic fluid leukemia inhibitory factor concentrations were elevated during intraamniotic infection and gestational tissues released leukemia inhibitory factor in response to bacterial products and inflammatory mediators.
- Publisher
- MOSBY-YEAR BOOK INC
- Keywords
- TUMOR NECROSIS FACTOR; PREGNANCY-ASSOCIATED INCREASE; AMNIOTIC-FLUID INTERLEUKIN-6; HUMAN DECIDUA; PROSTAGLANDIN PRODUCTION; PRETERM PARTURITION; MOUSE SERUM; LABOR; CELLS; BIOSYNTHESIS
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Creation Date: 1994-11-01 12:00:00