High-Affinity B Cell Receptor Ligation by Cognate Antigen Induces Cytokine-Independent Isotype Switching
- Author(s)
- Turner, ML; Corcoran, LM; Brink, R; Hodgkin, PD;
- Details
- Publication Year 2010-06-15,Volume 184,Issue #12,Page 6592-6599
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The selection of an appropriate Ig isotype is critical for an effective immune response against pathogens. Isotype regulation is sensitive to external signals, particularly cytokines secreted by Th cells. For example, IL-4 induces isotype switching to IgG1 via a STAT6-dependent signaling pathway. In this study, we show that BCR ligation also induces IgG1 switching in mouse B cells. The extent of switch induction by Ag is affinity-dependent, and high-affinity Ag binding leads to IgG1 switching levels comparable to those induced by saturating IL-4. However, the Ag-induced IgG1 switch does not require additional cytokine signals and occurs in a STAT6-independent manner. Thus, BCR ligation represents a novel pathway for direct isotype switching leading to IgG1 secretion. The Journal of Immunology, 2010, 184: 6592-6599.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- STIMULATORY FACTOR-I; PLASMA-CELL; INTERFERON-GAMMA; SECRETING CELLS; IGA PRODUCTION; LYMPHOCYTES-B; DIFFERENTIATION; LIPOPOLYSACCHARIDE; DIVISION; INTERLEUKIN-4
- Publisher's Version
- https://doi.org/10.4049/jimmunol.0903437
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2010-06-15 12:00:00