The colony-stimulating factors and cancer
- Author(s)
- Metcalf, D;
- Details
- Publication Year 2010-06,Volume 10,Issue #6,Page 425-434
- Journal Title
- NATURE REVIEWS CANCER
- Publication Type
- Journal Article
- Abstract
- The four colony-stimulating factors (CSFs) are glycoproteins that regulate the generation and some functions of infection-protective granulocytes and macrophages. Recombinant granulocyte-CSF (G-CSF) and granulocyte-macrophage-CSF (GM-CSF) have now been used to increase dangerously low white blood cell levels in many millions of cancer patients following chemotherapy. These CSFs also release haematopoietic stem cells to the peripheral blood, and these cells have now largely replaced bone marrow as more effective populations for transplantation to cancer patients who have treatment-induced bone marrow damage.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- BONE-MARROW-CELLS; BLOOD PROGENITOR CELLS; HIGH-DOSE CHEMOTHERAPY; MULTI-CSF IL-3; AUGMENTS ANTITUMOR IMMUNITY; SEVERE CHRONIC NEUTROPENIA; MOUSE HEMATOPOIETIC-CELLS; AUTOLOGOUS TUMOR VACCINES; MURINE GM-CSF; GROWTH-FACTOR
- Publisher's Version
- https://doi.org/10.1038/nrc2843
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2010-06-01 12:00:00