The colony-stimulating factors and cancer
Author(s)
Metcalf, D;
Details
Publication Year 2010-06,Volume 10,Issue #6,Page 425-434
Journal Title
NATURE REVIEWS CANCER
Publication Type
Journal Article
Abstract
The four colony-stimulating factors (CSFs) are glycoproteins that regulate the generation and some functions of infection-protective granulocytes and macrophages. Recombinant granulocyte-CSF (G-CSF) and granulocyte-macrophage-CSF (GM-CSF) have now been used to increase dangerously low white blood cell levels in many millions of cancer patients following chemotherapy. These CSFs also release haematopoietic stem cells to the peripheral blood, and these cells have now largely replaced bone marrow as more effective populations for transplantation to cancer patients who have treatment-induced bone marrow damage.
Publisher
NATURE PUBLISHING GROUP
Keywords
BONE-MARROW-CELLS; BLOOD PROGENITOR CELLS; HIGH-DOSE CHEMOTHERAPY; MULTI-CSF IL-3; AUGMENTS ANTITUMOR IMMUNITY; SEVERE CHRONIC NEUTROPENIA; MOUSE HEMATOPOIETIC-CELLS; AUTOLOGOUS TUMOR VACCINES; MURINE GM-CSF; GROWTH-FACTOR
Publisher's Version
https://doi.org/10.1038/nrc2843
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2010-06-01 12:00:00
An error has occurred. This application may no longer respond until reloaded. Reload 🗙