Antigen-Specific CD4 Cells Assist CD8 T-Effector Cells in Eliminating Keratinocytes
- Author(s)
- Broom, JK; Lew, AM; Azukizawa, H; Kenna, TJ; Leggatt, GR; Frazer, IH;
- Details
- Publication Year 2010-06,Volume 130,Issue #6,Page 1581-1589
- Journal Title
- JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Publication Type
- Journal Article
- Abstract
- Keratinocytes expressing tumor or viral antigens can be eliminated by antigen-primed CD8 cytotoxic T cells. CD4 T-helper cells help induction of CD8 cytotoxic T cells from naive precursors and generation of CD8 T-cell memory. In this study, we show, unexpectedly, that CD4 cells are also required to assist primed CD8 effector T cells in rejection of skin expressing human growth hormone, a neo-self-antigen, in keratinocytes. The requirement for CD4 cells can be substituted by CD40 costimulation. Rejection of skin expressing ovalbumin (OVA), a non-self-antigen, by primed CD8 cytotoxic T cells can in contrast occur without help from antigen-specific CD4 T cells. However, rejection of OVA expressing keratinocytes is helped by antigen-specific CD4 T cells if only low numbers of primed or naive OVA-specific CD8 T cells are available. Effective immunotherapy directed at antigens expressed in squamous cancer may therefore be facilitated by induction of tumor antigen-specific CD4 helper T cells, as well as cytotoxic CD8 T cells.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- DENDRITIC CELLS; NONLYMPHOID TISSUES; POSITIVE SELECTION; CROSS-PRESENTATION; RECALL RESPONSES; GRAFT-REJECTION; CUTTING EDGE; SKIN-GRAFTS; MEMORY; LYMPHOCYTES
- Publisher's Version
- https://doi.org/10.1038/jid.2010.17
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2010-06-01 12:00:00