Effector and memory CD8(+) T cell differentiation: toward a molecular understanding of fate determination
- Author(s)
- Belz, GT; Kallies, A;
- Details
- Publication Year 2010-06,Volume 22,Issue #3,Page 279-285
- Journal Title
- CURRENT OPINION IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- CD8(+) T cells play a key role in protecting the body against invading microorganisms. Their capacity to control infection relies on the development of peripheral effector and memory T cells. Much of our current knowledge has been gained by tracking alterations of the phenotype of CD8(+) T cells but the molecular understanding of the events that underpin the emergence of heterogeneous effector and memory CD8(+) T cells in response to infection has remained limited. This review focuses on the recent progress in our understanding of the molecular wiring of this differentiation process.
- Publisher
- CURRENT BIOLOGY LTD
- Keywords
- TRANSCRIPTIONAL REPRESSOR BLIMP-1; IL-7 RECEPTOR-ALPHA; CUTTING EDGE; B-CELLS; SELECTIVE EXPRESSION; LINEAGE RELATIONSHIP; VIRAL-INFECTION; BET; SUBSETS; EOMESODERMIN
- Publisher's Version
- https://doi.org/10.1016/j.coi.2010.03.008
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2010-06-01 12:00:00