Robert Koch redux: malaria immunology in Papua New Guinea
- Author(s)
- Stanisic, DI; Mueller, I; Betuela, I; Siba, P; Schofield, L;
- Details
- Publication Year 2010-08,Volume 32,Issue #8,Page 623-632
- Journal Title
- PARASITE IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- P>Over a century ago, the malaria expedition of the brilliant microbiologist Robert Koch to the Dutch East Indies (Indonesia) and German New Guinea (now Papua New Guinea, or PNG), resulted in profound observations that are still central to our current understanding of the epidemiology and acquisition of immunity to the malaria parasite Plasmodium. The tradition of malaria research in PNG pioneered by Koch continues to this day, with a number of recent studies still continuing to elucidate his original concepts and hypotheses. These include age and exposure-related acquisition of immunity, species-specific and cross-species immunity, correlates of protective immunity and determining the prospects for anti-malaria vaccines.
- Publisher
- WILEY-BLACKWELL
- Keywords
- DUFFY-BINDING-PROTEIN; HIGHLY ENDEMIC AREA; PLASMODIUM-FALCIPARUM MALARIA; ERYTHROCYTE SURFACE-ANTIGEN; ACQUIRED ANTIBODY-LEVELS; CELL-MEDIATED-IMMUNITY; HUMORAL RESPONSE; INTERFERON-GAMMA; CLINICAL MALARIA; CHILDREN
- Publisher's Version
- https://doi.org/10.1111/j.1365-3024.2010.01238.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2010-08-01 12:00:00