Regulation of interleukin-1 beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production
- Author(s)
- Masters, SL; Mielke, LA; Cornish, AL; Sutton, CE; O'Donnell, J; Cengia, LH; Roberts, AW; Wicks, IP; Mills, KHG; Croker, BA;
- Details
- Publication Year 2010-08,Volume 11,Issue #8,Page 640-646
- Journal Title
- EMBO REPORTS
- Publication Type
- Journal Article
- Abstract
- Reports describing the effect of interferon-gamma (IFN gamma) on interleukin-1 beta (IL-1 beta) production are conflicting. We resolve this controversy by showing that IFN gamma potentiates IL-1 beta release from human cells, but transiently inhibits the production of IL-1 beta from mouse cells. Release from this inhibition is dependent on suppressor of cytokine signalling 1. IL-1 beta and Th17 cells are pathogenic in mouse models for autoimmune disease, which use Mycobacterium tuberculosis (MTB), in which IFN gamma and IFN beta are anti-inflammatory. We observed that these cytokines suppress IL-1 beta production in response to MTB, resulting in a reduced number of IL-17-producing cells. In human cells, IFN gamma increased IL-1 beta production, and this might explain why IFN gamma is detrimental for multiple sclerosis. In mice, IFN gamma decreased IL-1 beta and subsequently IL-17, indicating that the adaptive immune response can provide a systemic, but transient, signal to limit inflammation.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- NECROSIS-FACTOR CACHECTIN; IL-1 INDUCES IL-1; IFN-GAMMA; SECRETION; MACROPHAGES; INHIBITION; TRANSCRIPTION; ACTIVATION; IL-1-BETA; MONOCYTES
- Publisher's Version
- https://doi.org/10.1038/embor.2010.93
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2010-08-01 12:00:00