Fighting cancers from within: augmenting tumor immunity with cytokine therapy
- Author(s)
- Pellegrini, M; Mak, TW; Ohashi, PS;
- Details
- Publication Year 2010-08,Volume 31,Issue #8,Page 356-363
- Journal Title
- TRENDS IN PHARMACOLOGICAL SCIENCES
- Publication Type
- Journal Article
- Abstract
- The human immune system has successfully evolved to fight many pathogens. Through vaccination, we can harness and improve immune responses to eradicate infections. Despite this success, we are only now beginning to understand the natural tumor immune surveillance mechanisms and why, in some instances, our immune system fails to abrogate the development and growth of tumors. Encouraging results with the latest immunotherapies have renewed enthusiasm in the field. A central component of these therapies is the contribution of cytokines. Here we review our expanding knowledge of cytokine-induced effects as well as preclinical and clinical data that indicate adjuvant cytokine therapies may hold much promise in improving anti-tumor immunity. Further studies on optimal synergistic combinations, timing, duration and additional adjuvant therapies are required to realize the full potential of cytokines as immunotherapeutic agents.
- Publisher
- ELSEVIER SCIENCE LONDON
- Keywords
- CD8(+) T-CELLS; CHRONIC VIRAL-INFECTION; IN-VIVO; METASTATIC MELANOMA; ADOPTIVE IMMUNOTHERAPY; ESTABLISHED TUMORS; ANTITUMOR-ACTIVITY; DENDRITIC CELLS; ADJUVANT IL-7; PHASE-I
- Publisher's Version
- https://doi.org/10.1016/j.tips.2010.05.003
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2010-08-01 12:00:00