Resident and Monocyte-Derived Dendritic Cells Become Dominant IL-12 Producers under Different Conditions and Signaling Pathways
- Author(s)
- Zhan, YF; Xu, YK; Seah, S; Brady, JL; Carrington, EM; Cheers, C; Croker, BA; Wu, L; Villadangos, JA; Lew, AM;
- Details
- Publication Year 2010-08-15,Volume 185,Issue #4,Page 2125-2133
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- IL-12 is such a pivotal cytokine that it has been called the third signal for T cell activation, TCR engagement being the first and costimulation being the second. It has been generally viewed that the resident CD8(+) dendritic cell (DC) subset is the predominant IL-12-producing cell type. In this study, we found, although this is so under steady state conditions, under inflammatory conditions monocyte-derived DC (mDC) became a major cell type producing IL-12. Depletion of either type of DC resulted in reduced production of IL-12 in vivo. For CD8(+) DC, IL-12 production could be stimulated by various pathways viz. signaling through MyD88, Trif, or nucleotide-binding oligomerization domain (Nod)-like receptors. In contrast, for mDC, IL-12 production was mainly dependent on MyD88 signaling. Thus, conventional DCs and mDCs use different pathways to regulate IL-12 production. The Journal of Immunology, 2010, 185: 2125-2133.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- COLONY-STIMULATING FACTOR; TUMOR-NECROSIS-FACTOR; IN-VIVO; LISTERIA-MONOCYTOGENES; FLT3 LIGAND; T-CELLS; BACTERIAL-INFECTION; CROSS-PRESENTATION; ADAPTIVE IMMUNITY; RECEPTOR LIGANDS
- Publisher's Version
- https://doi.org/10.4049/jimmunol.0903793
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2010-08-15 12:00:00